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To determine whether telmisartan increases FMD, we performed a meta-analysis of these trials.

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Once data from the direct comparator trials had been abstracted, we identified 3 categories of outcomes that we thought were underreported in these trials: death and major events (myocardial infarction, stroke), measures of carbohydrate metabolism or diabetes control (progression to type 2 diabetes, hemoglobin A 1c, insulin or other diabetes medication dosage, fasting plasma glucose, or aggregated measures of serial glucose measurements), and measures of kidney disease (creatinine level, glomerular filtration rate, and proteinuria).

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